RTA (or Real Time Attack) is a group of categories that is timed in a single-segment. Runs usually follow a real timer rather than the in-game timer, as the in-game timer is faster and does not count the time spent in menu and loading screens.
In the following categories, you are allowed to use your own episode route. You can go in order, or go completely out of order - you only need to complete the first/original 3 episodes: L.A. Meltdown, Lunar Apocalypse, and Shrapnel City. Other subcategories may include the fourth episode, The Birth, or other expansion packs.

Any% (Glitchless)

Route

E1L1 - Hollywood Holocaust

If you have run this level in standard Any% before, then the route will seem very familiar.

1. Shoot or kick the fan vent in the top of the level, fall down and start moving diagonally forward+right.
2. Jump onto the crate where the Assault Trooper is standing; you do not have to kill it, and then jump into a window diagonally up+left.
3. Head to the poster in the secret room and open it, then grab the steroids.
4. Using the steroids, jump out of a window onto the wall on the other side.
5. Head down the wall and jump forward+left onto the ledge near the Auto Destruct button.
6. Shoot or kick the glass and finish the level.

E1L2 - Red Light District

1. Head out of the elevator you start the level in and into the shop on the left.
2. Kill the Pig Cop that may be in your way if you wish to.
3. Head right to the red door, grabbing the Atomic Health and Shotgun on the other end if you wish to.
4. Solve the button puzzle, head into the new room and use the elevator on the other end.
   (Solution: on; off; on)
5. Heading to the right, grab the Blue Access Card and shoot and jump out of the glass window further onto the right of the room.
6. Head forwards to the booth beyond the door requiring the Yellow Access Card, and kill the Pig Cop.
7. Use the Blue Access Card and solve the button puzzle that appears.
   (Solution: off; on; on; off)
8. Flip the switch that appears in front of you and run to the pillar just in front of the building that is now falling.
   
9. After waiting for the explosions to stop, run diagonally forward+right and grab the Yellow Access Card. A medkit is on the other end near the sewer if you need it.
10. Head back to the red door you passed earlier and use the Yellow Access Card.
11. Ignore the Pig Cop on the right as you enter and head left.
12. Turn and head right into the bar (the first hall you come to on your right beyond the pool table). There will be a cabinet under the wall with liquor bottles.
13. Ignore all enemies and grab the Red Access Card in the cabinet.
14. Head out of the bar, evading the 3 Pig Cops that just spawned, and into the next hall.
15. Use the Red Access Card and, ignoring everything in the new room, shoot the air vent on the right.
16. Jump into the now open air vent (there is a table you can use to jump into it if need be), grab the items in it and shoot/kick the air vent on the other end.
17. Use the Pig Cop standing in front of the ledge and jump onto it. Jump off the Pig Cop onto the ledge and follow it down to the end of the level.
    If you have ran Any% before and are using the Megaton Edition, do not use the Death Row skip as that is a glitch and will invalidate the run.
18. Walk into the end level trap as intended.

E1L3 - Death Row

1. Head right and kick the glass window open. Jump into the room, and push the button on the right. A pistol and some ammo is on the other end if you need it.
2. Jump out of the room using the window you just kicked out, and shoot/kick the glass behind the opening curtains.
3. Jump out and head forwards, ignoring the enemies. A medkit is in front of the cell door if you need it.
4. Keep going down the hall until you get near the red door requiring a Blue Access Card. A hole to your left will explode open leading to a new room. Head into it.
5. Jump on the gears to the room ahead of them, and grab the RPG and Blue Access Card near the Assault Trooper firing at you. A +30 Health is on the other end if you need it.
6. Head out of the gear room and back to the red door requiring the Blue Access Card. Use the Card and crouch underneath the Laser Tripbomb.
7. Ignore the Pig Cops and head forwards. Head into the first room on your left and jump over the Laser Tripbomb that just activated. You will need to be quick in this room or you will kill yourself.
8. Grab the Yellow Access Card and jump out just before you get to the slanted part of the floor. This will allow you just enough height not to hit the 2 Laser Tripbombs in front of you.
9. Head left or right to the large room below you. Use the RPG to kill the Pig Cops in the room if you need to.
10. Use the Yellow Access Card on the metal doors in the front of the room. Ignore the 2 Pig Cops on the right.
11. Head forwards through the hall and head left once you get outside. Grab the Red Access Card and head back inside.
12. On the other end of the room on either the left or right, use the Red Access Card. Kill any enemy in your way if you need to.
13. Press/shoot the button ahead of you and head into the room that slid open.
14. Press/shoot the button on the other end to reveal 2 doors behind you. Head into the one on the right (the switch on the inside should be labeled "02").
15. Kill the Pig Cop if needed and flip the switch off.
16. Head back into the circular room and shoot the button under the air vent.
17. Keep your aim steady and head out of the circular room using the metal doors on your right.
18. Crouch under the Laser Tripbomb and head to the hall on your right, killing any enemies you need to.
19. Once you come to a switch, switch it to the 3rd option. Ignore the enemies you encounter.
20. In the 3rd room, go behind the picture on the right, grab the pipebombs on the end of the hidden hole you just went into, and blow up the end of it.
21. Blow up the new end and continue heading outside via the sewer.
22. Head underwater and go underneath the submarine. Enter it via the opening under it.
23. Kill the enemy in the way of the Auto Destruct button if need be, kick/shoot the glass, and end the level.

E1L4 - Toxic Dump

1. Head underwater and solve the button puzzle.
   (Solution: on; off; on)
2. An opening will start to appear on the left. Wait for it to open enough and head out moving up to the surface and diagonally forward+left.
3. Enter the hole in the wall (grabbing the +30 Health if you need it) and kill the Assault Trooper at the top.
4. Grab the RPG on your left and the Blue Access Card on your right. Jump off the ledge and head to the red door requiring the Blue Access Card on the other end of the area on the left.
5. Use the Blue Access Card and follow the hallway down the the red door on your left.
6. Enter the room and look up behind the pillar in front of you. Shoot the Laser Tripbomb with your RPG or else you risk killing yourself.
7. Shoot the barrel of toxic waste on the conveyor belt and step onto the caution area. Kill the Assault Trooper on the left if you need to, but be sure to switch away from the RPG.
8. Let the claw grab you from above and move you onto the higher conveyor belt. Shoot the barrel of toxic waste in front of you and step onto the caution area.
9. Let the other claw grab you and move you in front of an area sealed off by glass. Kill the Pig Cop behind it and head into the room.
10. Grab the Red Access Card and head back into the main room. Head diagonally forward+left to the room with 2 tiny entrances on the left and right.
11. Use the Red Access Card and let the shrinker behind it hit you. Head into the next room using the entrance on the right and wait in a corner to grow back to full size. Enemies can and will crush you to your death if they can get to you.
12. Kill the Assault Trooper in the room and flip the switch on. Let the shrinker hit you and head back to the other room. Go in to the new hall that opened on the right and wait to grow back to full size.
13. Head underwater moving diagonally forward+left and press/shoot the button in the room past the mines.
14. Head to the surface and wait for the water level to rise enough. Be in front of the toxic waterfall and grab the steroids to the left of it.
15. Using the steroids, head to the small ledge on the other end and jump off the small cliff on the right while moving forwards. This takes you to a teleporter which allows you to skip the rest of the level. TheBlackParrot demonstrates this in this YouTube video.
16. Open the door in front of you and use the Auto Destruct button on your left.

The skip used in the last part of the level is not considered a glitch, as no glitches are needed to access it.

E1L5 - The Abyss

1. Head down the sewer and onto the narrow ledge on the left.
2. Once you get to the end of the ledge, grab the Blue Access Card and head back to the toxic waste.
3. Go left and use the Blue Access Card. Head down the passageway to the next ledge on the left, killing any enemies you need to.
4. Stay right down the other passage way and jump onto the cliff in front of you. Step in front of the "SAN ANDREAS FAULT" sign to trigger the earthquake.
5. Jump onto one of the falling cliffs (the one of the left that falls quicker has an Atomic Health) and jump down into the stream of toxic waste.
6. Kill the Pig Cop if you need to and head down the passage way. Head to the one on the far left and ignore the Octabrain.
7. Fall into the hole at the end of it and press the hand on the right.
8. Head into the narrow passageway and kill the Octabrain (if you need to) in the next room. Use the hand near it to trigger a staircase slightly beyond it.
   Try to press it and jump onto the last part of the staircase to save time.
9. Make sure as you step off the staircase that you trigger the next earthquake. It may not trigger if you move too fast and it will waste time.
10. Press the next hand in front of you and jump on the ledge rising up on the right.
11. Press the hand above it and wait for the shrinker on the far end to hit you. Head into the next area via the small passageway on the floor to the right.
12. Go into the toxic waste and head forwards. Another passageway will be beyond the toxic waste. Grab the Atomic Health if you need it.
13. Follow the next few passageways and kill any enemies in your way if you need to.
14. Once you get to a metal door, open it and head down to the opening door. The Octabrain at the end of it is usually of no threat.
15. Press the button on the right behind the opening door and fall down the hole. If you stay left as you fall down the hole, a small opening with an RPG will be waiting.
16. Head into the boss room in front of you by pressing the button near the doors. 15 RPG ammo is on your left if you need it.
17. Grab the medkit (use your previous one if you have one) and grab the Atomic Health near the Battlelord. Kill it and finish the episode.

5 RPG ammo is on each corner of the toxic waste, but about 20 total is optimal to kill the Battlelord.